Half human, half vampire, Blade can survive full sunlight and wants to rid the world of vampires; Blade and Whistler must join forces with Blade's sworn enemies to destroy a new breed of super vampire; when the FBI becomes aware of his existence, Blade joins a group of human vampire hunters, the Nightstalkers, to find the original vampire; Blade joins forces with a beautiful Nightstalker when he unmasks the plan of an evil sect of vampires to destroy...